Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group.
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چکیده
منابع مشابه
Synthesis, Characterization, and Biological Activity Studies on Fanlizhicyclopeptide A
The synthesis of a proline-rich cyclic heptapeptide, fanlizhicyclopeptide A (8), previouslyisolated from the fruits of Annona squamosa (sugar-apples), is described via coupling oftetrapeptide l-prolyl-l-tyrosyl-l-leucyl-l-proline methyl ester with tripeptide Boc-glycyl-lvalyl-l-proline followed by cyclization of the linear fragment having seven amino acid units.Structure of the synthesized cycl...
متن کاملSynthesis, Characterization, and Biological Activity Studies on Fanlizhicyclopeptide A
The synthesis of a proline-rich cyclic heptapeptide, fanlizhicyclopeptide A (8), previouslyisolated from the fruits of Annona squamosa (sugar-apples), is described via coupling oftetrapeptide l-prolyl-l-tyrosyl-l-leucyl-l-proline methyl ester with tripeptide Boc-glycyl-lvalyl-l-proline followed by cyclization of the linear fragment having seven amino acid units.Structure of the synthesized cycl...
متن کاملSynthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone.
Two platelet-activating factor (PAF) analogs containing a methyl group at C2 of the glycerol moiety were synthesized, and some of their biochemical properties were investigated. 1-O-Hexadecyl-2-C,O-dimethyl-rac-glycero-3-phosphocholine (2-methyl-2-methoxy PAF) was prepared in a synthetic scheme beginning with the etherification of 2-methylpropen-1-ol. A reaction sequence involving hydroxylation...
متن کامل3,3(')-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group.
3,3(')- Oxybis(dimethoxytrityl chloride) (O-DMTCl) was synthesized as a novel, acid-labile bifunctional protecting reagent. The reactions of O-DMTCl with base-protected ribonucleosides afforded unexpectedly 2('),5(')-cyclic protected ribonucleosides in addition to the expected 3('),5(')-cyclic protected ribonucleosides in good yields.
متن کاملStannous Chloride: A Reagent for Removal of Dimethoxytrityl Group from 5'-Dimethoxytrityl Nucleosides
Detritylation of 5'-dimethoxytrityl nucleosides have been quantitatively achieved in minutes at room temperature under aprotic neutral conditions by using stannous chloride. Of additional practical consideration and in contrast to protic acids, no depurination was observed with this reagent.
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 1998
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.1998_4315